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pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can lower panobinostat concentrations by ~70% and result in therapy failure.Although it can be utilized as a sedative and anticonvulsant by doctors, just 10 grams of Nembutal is sufficient to induce respir